Reaction products of 2-substituted-4-chlorobenzofuro [3,2-d] pyrimidines and their antimicrobial activities

Abstract

The nucleophilic displacement reaction of 2-substituted-4-chlorobenzofuran [3,2-d] pyrimidines 4-5 with nucleophiles such as sodium methoxide, sodiumethoxide and thiourea furnished 2-substituted-4-methoxy/ethoxy benzofuro [3,2-d] pyrimidines 6-9 and 2-substituted-3,4-dihydro-4-thiobenzofuro [3,2-d] pyrimidines 10-11 respectively. All the synthesized compounds were characterized on the basis of analytical and spectral data. These compounds were screened for their antimicrobial activities.