Please use this identifier to cite or link to this item: http://gukir.inflibnet.ac.in:8080/jspui/handle/123456789/4771
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dc.contributor.authorAnekal D.P
dc.contributor.authorBiradar J.S.
dc.date.accessioned2020-06-12T15:04:51Z-
dc.date.available2020-06-12T15:04:51Z-
dc.date.issued2013
dc.identifier.citationJournal of Chemical and Pharmaceutical Research , Vol. 5 , 1 , p. 75 - 85en_US
dc.identifier.urihttp://gukir.inflibnet.ac.in:8080/jspui/handle/123456789/4771-
dc.description.abstractSome novel 2-(5-substituted-3-phenyl-1H-indol-2-yl)-5-methyl/phenyl-7H-[1, 3, 4] oxadiazolo/thiadiazolo [3, 2-a] [1, 3, 5] triazine-7-thiones (6&7a-f) were prepared from the intra molecular cyclocondensation of N-((5-(5-substituted-3-phenyl-1H-indol-2-yl)-1, 3, 4-oxadiazol/thiadiazol-2-yl)carbamothioyl)acetamides/benzamides (4& 5a-f). Which were occurred from the condensation of 5-(5-substituted-3-phenyl-1H-indol-2-yl)-1, 3, 4-oxadiazol/thiadiazol-2-amine (2&3a-c) with acetyl and benzoyl chlorides in the presence of ammonium thiocynate. The compounds 2a-c & 3a-c were obtained from base and acid catalyzed cyclisation reactions of 2-(5-substituted-3-phenyl-1H-indole-2-carbonyl) hydrazine carbothioamides (1a-c) in ethanol. The compounds synthesized were characterized by using their spectral (IR, NMR and Mass) and analytical studies. All synthesized molecules are evaluated to in-vitro antimicrobial activities against various microbial strains. Most of the new molecules are displayed moderate to significant activities towards antibacterial and antifungal strains.en_US
dc.subject3, 5-disubstituted indoles
dc.subjectAntimicrobial
dc.subjectFisher indole synthesis
dc.subjectFused heterocycles
dc.subjectS-triazines
dc.titleSynthesis, characterization and antimicrobial activities of 2-(5-substituted-3-phenyl-1H-indol-2-yl)-5-substituted-7H-[1, 3, 4] oxadiazolo/thiadiazolo[3, 2-a] [1, 3, 5] triazine-7-thionesen_US
dc.typeArticle
Appears in Collections:1. Journal Articles

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