SYNTHESIS OF NEW 3-(BENZO [d] IMIDAZOL-2-YL AMINO)-2-(3-ARYL-1-PHENYL-1H-PYRAZOL-4-YL) THIAZOLIDIN-4-ONES

Abstract

Reaction of 2-hydrazinobenzimidazole (1) with 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehydes (2a-f) in ethanol yielded the corresponding Schiff's bases (3a-f). Further, cyclization of compounds 3a-f with thioglycollic acid in benzene in presence of anhyd ZnCl(2) furnished desired compounds 3-(benzo [d] imidazol-2-ylamino)-2-(3-aryl-1-phenyl-1H-pyrazol-4-y1) thiazolidin-4-ones (4a-f) in 41-65% yield. All the synthesized compounds were characterized by the spectral data such as IR, (1)H NMR, mass and elemental analysis.