Effect of atropine sulphate on ovarian activities in albino rats

Abstract

Atropine sulphate at the dose level of 0.1mg & 0.2mg/100gm body weight administration for 30 days to the cycling albino rats, caused decrease in the ovarian weight, showing a decreasing number of developing follicles, Graafian follicles and corpora lutea, and an increased number of atretic follicles in histological sections. The estrous cycles of these rats were irregular with prolonged diestrus and reduced proestrus, estrus and metaestrus phases also support the decreased estrogen synthesis. Responsible for cornification of vaginal smear in Atropine sulphate treated rats. The hisometric changes of diameter of the ovarian follicles are reduced significantly. The total cholesterol content of the ovary was increased; protein and glycogen content were decreased.