Synthesis and antimicrobial activities of some new benzofuro [3,2-d] pyrimidines

Abstract

2-(4-Nitrophenyl)-3,4-dihydro-4-oxobenzofuro [3,2-d] pyrimidine 2 was prepared by the reaction of 3-amino-2-benzofurancarboxamide 1 with 4-nitrobenzaldehyde in presence of catalytic quantity of cone hydrochloric acid. The nucleophilic displacement reaction of compound 2 with phosphorus oxychloride furnished 2-(4-nitrophenyl-3,4-dihydro-4-chlorobenzofuro [3,2-d] pyrimidine 3. The benzofuro [3,2-d] pyrimidine derivatives (4-12) were prepared by the reaction of compound 3 with aliphatic primary amines, secondary amines and aromatic amines. Synthesized compounds were characterized on the basis of spectral and analytical data. All the compounds were screened for biological activity.