Please use this identifier to cite or link to this item: http://gukir.inflibnet.ac.in:8080/jspui/handle/123456789/4385
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dc.contributor.authorRaghunath S.A
dc.contributor.authorManjunatha Y
dc.contributor.authorRayappa K.
dc.date.accessioned2020-06-12T15:03:44Z-
dc.date.available2020-06-12T15:03:44Z-
dc.date.issued2012
dc.identifier.citationMedicinal Chemistry Research , Vol. 21 , 11 , p. 3809 - 3817en_US
dc.identifier.uri10.1007/s00044-011-9915-7
dc.identifier.urihttp://gukir.inflibnet.ac.in:8080/jspui/handle/123456789/4385-
dc.description.abstractTo examine new leads with potential antimicrobial and antioxidant activities, a new series of tetrahydropyrimidines (2a-c, 3a-c and 4a-c), pyrazolo[3, 4-d]pyrimidines (5a-c), and ditetrazolo[1,5-A;10,50-c] pyrimidines (6a-c) were synthesized in this study using appropriate synthetic routes. The newly synthesized compounds have been tested for their antimicrobial and antioxidant activities against DPPH stable free radical. In the case of antibacterial activity, compounds 2a, 6a, and 6c exhibited the maximum zone of inhibition against Staphylococcus aureus; compound 6c exhibited maximum zone of inhibition against Pseudomonas aeruginosa; and compound 2a showed maximum inhibitory growth against Klebsiella pneumonia. While in the case of antifungal activities, compound 5a showed good zone of inhibition against Aspergillus oryzae, compounds 2b and 6a exhibited maximum zone of inhibition against Aspergillus niger. In case of antioxidant activities, compound 2a showed the highest DPPH radical scavenging activity. © Springer Science+Business Media, LLC 2011.en_US
dc.subjectAntimicrobial
dc.subjectAntioxidant
dc.subjectIndole
dc.subjectPyrazolopyrimidine
dc.subjectTetrazolopyrimidines
dc.titleSynthesis, antimicrobial, and antioxidant activities of some new indole analogues containing pyrimidine and fused pyrimidine systemsen_US
dc.typeArticle
Appears in Collections:1. Journal Articles

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