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dc.contributor.authorMahendra Raj K
dc.contributor.authorMruthyunjayaswamy B.H.M.
dc.date.accessioned2020-06-12T15:02:40Z-
dc.date.available2020-06-12T15:02:40Z-
dc.date.issued2014
dc.identifier.citationJournal of Molecular Structure , Vol. 1074 , , p. 572 - 582en_US
dc.identifier.uri10.1016/j.molstruc.2014.06.039
dc.identifier.urihttp://gukir.inflibnet.ac.in:8080/jspui/handle/123456789/4206-
dc.description.abstractSchiff base ligand 3-chloro-N?-((7-hydroxy-4-methyl-2-oxo-2H-chromen- 8-yl)methylene)benzo[b]thiophene-2-carbohydrazide and its Cu(II), Co(II), Ni(II) and Zn(II) complexes were synthesized, characterized by elemental analysis and various physico-chemical techniques like, IR, 1H NMR, ESI-mass, UV-Visible, thermogravimetry - differential thermal analysis, magnetic measurements and molar conductance. Spectral analysis indicates octahedral geometry for all the complexes. Cu(II) complex have 1:1 stoichiometry of the type [M(L)(Cl)(H2O)2], whereas Co(II), Ni(II) and Zn(II) complexes have 1:2 stoichiometric ratio of the type [M(L)2]. The bonding sites are the oxygen atom of amide carbonyl, nitrogen of azomethine function and phenolic oxygen of the Schiff base ligand via deprotonation. The thermogravimetry - differential thermal analysis studies gave evidence for the presence of coordinated water molecules in the composition of Cu(II) complex which was further supported by IR measurements. All the complexes were investigated for their electrochemical activity, but only the Cu(II) complex showed the redox property. In order to evaluate the effect of antimicrobial potency of metal ions upon chelation, ligand and its metal complexes along with their respective metal chlorides were screened for their antibacterial and antifungal activities by minimum inhibitory concentration (MIC) method. The results showed that the metal complexes were found to be more active than free ligand. Ligand and its complexes were screened for free radical scavenging activity by DPPH method and DNA cleavage activity using Calf-thymus DNA (Cat. No-105850). © 2014 Elsevier B.V. All rights reserved.en_US
dc.publisherElsevier
dc.subjectAntimicrobial and antioxidant activity
dc.subjectBenzo[b]thiophene
dc.subjectCoumarin
dc.subjectElectrochemistry
dc.titleSynthesis, spectroscopic characterization, electrochemistry and biological evaluation of some metal (II) complexes with ONO donor ligand containing benzo[b]thiophene and coumarin moietiesen_US
dc.typeArticle
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