Please use this identifier to cite or link to this item: http://gukir.inflibnet.ac.in:8080/jspui/handle/123456789/4150
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dc.contributor.authorKirankumar, B
dc.contributor.authorKulkarni, GB
dc.contributor.authorSanjeevkumar, S
dc.contributor.authorMukram, I
dc.contributor.authorKaregoudar, TB
dc.date.accessioned2020-06-12T15:02:31Z-
dc.date.available2020-06-12T15:02:31Z-
dc.date.issued2014
dc.identifier.citationAPPLIED BIOCHEMISTRY AND BIOTECHNOLOGY , Vol. 173 , 5 , p. 1263 - 1273en_US
dc.identifier.uri10.1007/s12010-014-0930-2
dc.identifier.urihttp://gukir.inflibnet.ac.in:8080/jspui/handle/123456789/4150-
dc.description.abstractThe present study describes the N,N-dimethylformamide (DMF)-induced oxidative stress in Paracoccus sp. SKG. The oxidative stress was evaluated by analysing membrane and periplasmic proteins and K+ efflux, as well as by monitoring the activities of antioxidant enzymes like catalase, superoxide dismutase (SOD) and glutathione S-transferase (GST). The exposure of bacterial cells to a higher concentration of DMF resulted in the modification of membrane fatty acid composition which is accompanied by K+ efflux. Further, this oxidative stress resulted in increased periplasmic protein which can be attributed to the induction of GST and methionine sulphoxide reductase (Msr) enzymes under solvent stress. Paracoccus sp. SKG is tolerant to high concentrations of DMF up to 6 % (v/v) and its toxic effects. DMF concentration-dependent induction of GST and Msr activities advocates the significant role of these enzymes in the bacterial defence system. The present study provides information which helps us to understand the ROS scavenging machinery in bacteria. The high tolerance of Paracoccus sp. SKG to DMF can be efficiently explored for various bioremediation and biotransformation applications.en_US
dc.publisherHUMANA PRESS INC
dc.subjectDMF
dc.subjectPeriplasmic protein
dc.subjectGlutathione S-transferase
dc.subjectMethionine sulphoxide reductase
dc.subjectOxidative stress
dc.subjectParacoccus sp
dc.titleInfluence of DMF-Induced Oxidative Stress on Membrane and Periplasmic Proteins in Paracoccus sp SKGen_US
dc.typeArticle
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