Please use this identifier to cite or link to this item: http://gukir.inflibnet.ac.in:8080/jspui/handle/123456789/4077
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dc.contributor.authorWalmik P
dc.contributor.authorSaundane A.R.
dc.date.accessioned2020-06-12T15:02:18Z-
dc.date.available2020-06-12T15:02:18Z-
dc.date.issued2015
dc.identifier.citationDer Pharma Chemica , Vol. 7 , 6 , p. 131 - 140en_US
dc.identifier.urihttp://gukir.inflibnet.ac.in:8080/jspui/handle/123456789/4077-
dc.description.abstractThe present study envisaged the development of novel antioxidant, antimicrobial and antitubercular candidates using the indole scaffold. Several novel indole derivatives (3a-i) were prepared. The structures of these compounds were confirmed by their elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data. All the synthesized compounds 3a-i were screened for their in vitro antioxidant activity by various methods such as 1,1-Diphenyl-2- picryl hydrazyl (DPPH) radical scavenging activity (RSA), Ferric ions (Fe3+) reducing antioxidant power (FRAP) and Ferric ions (Fe3+) reducing antioxidant power (FRAP) antimicrobial and antitubercular activities. In vitro antioxidant, antimicrobial and antitubercular activities Compounds 3a and 3c exhibited good RSA and FRAP at a concentration 100 ?g/mL.Compounds 3a and 3c exhibited good metal chelating activity at a concentration 100 ?g/mL. Compound 3a exhibited promising antitubercular activity MIC 3.125 ?g/mL. Compound 3a exhibitted potent antimicrobial activity with MIC 125 ?g/mL against K. pneumonia (NCTC-13368) and Aspergillus terreus (MTCC- 1782). Whereas, the compound 3a exhibited promising antitubrcular activity against mycobacterium tuberculosis (ATCC-2794) with MIC 3.125 ?g/mL.en_US
dc.publisherScholars Research Library
dc.subjectAntimicrobial
dc.subjectAntioxidant
dc.subjectAntitubercular
dc.subjectAzetidinone
dc.subjectIndole
dc.subjectThiazolidinone
dc.titleSynthesis of novel indolyl-thiazolidinone derivatives as antioxidant, antimicrobial and atitubercular agentsen_US
dc.typeArticle
Appears in Collections:1. Journal Articles

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