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DC Field | Value | Language |
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dc.contributor.author | Sharma A | |
dc.contributor.author | Sharma P | |
dc.contributor.author | Singh S | |
dc.contributor.author | Karegoudar T.B | |
dc.contributor.author | Holla H. | |
dc.date.accessioned | 2020-06-12T15:02:09Z | - |
dc.date.available | 2020-06-12T15:02:09Z | - |
dc.date.issued | 2019 | |
dc.identifier.citation | European Journal of Integrative Medicine , Vol. 32 , , p. - | en_US |
dc.identifier.uri | 10.1016/j.eujim.2019.101000 | |
dc.identifier.uri | http://gukir.inflibnet.ac.in:8080/jspui/handle/123456789/4004 | - |
dc.description.abstract | Introduction: Goniothalamus wynaadensis Bedd. is a less explored medicinal plant belonging to the family Annonaceae. This species has been traditionally used by tribes of Wayanad, Kerala, in India, and also Indonesian tribes for joint-related ailments and also as a deodorizer. The aim of the study was to analyze leaf extracts of the plant for their antimicrobial and anticancer properties along with phytochemical screening. Methods: MTT assay was used to assess the cytotoxic potential of plant extracts against MDA-MB-231 and A-549. Antimicrobial potential of plant extracts was analyzed via liquid broth turbidometry assay and well in agar plate methods. Identification tests were carried out for phytochemical screening. Results: Antimicrobial assay showed EC50 values for ethyl acetate extract 0.82 mg/mL against Escherichia coli, 0.82 mg/mL against Salmonella typhi, & 0.88 mg/mL against Staphylococcus aureus which are quite significant. Other solvent extracts also displayed antimicrobial activities at varying dosage. MTT assay was performed at the dose concentrations of 1 ?g/mL, 5 ?g/mL & 25 ?g/mL, 50 ?g/mL and 100 ?g/mL to confirm the cytotoxicity of the extracts. The ethyl acetate extract displayed EC50 values of 4.96 ?g/mL against A-549 lung cancer cell line and 2.50 ?g/mL against MDA-MB-231 breast cancer cell line. Other extracts were also found to be cytotoxic. Conclusion: Ethyl acetate & water extracts have demonstrated potent activity against Salmonella typhi, Escherichia coli, & Staphylococcus aureus bacteria as well as, showing cytotoxicity against tested cancer cell lines. These results can be explored to identify individual phyto-molecules from the extracts with anticancer & antimicrobial potential. © 2019 Elsevier GmbH | en_US |
dc.publisher | Elsevier GmbH | |
dc.subject | Anticancer activity | |
dc.subject | Antimicrobial activity | |
dc.subject | Goniothalamus wynaadensis Bedd | |
dc.subject | Phytochemical screening | |
dc.subject | Survival index | |
dc.subject | Turbidometric analysis | |
dc.title | Evaluation of leaves of Goniothalamus wynaadensis Bedd. for inhibition of metabolic viability of cancer cells & antimicrobial efficacy | en_US |
dc.type | Article | |
Appears in Collections: | 1. Journal Articles |
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